科学研究:承担“抗流感病毒类Nucleozin衍生物的设计、合成和生物活性评价““长效胰岛素类似物的设计、制备及降血糖活性评价” 等基金项目4项;承担“新型吲哚系列小分子化合物设计及合成”“高性能碳纤维的开发” 等横向科研项目3项;发表高水平SCI学术论文40余篇、发明专利2项等。
教研教改:承担《药物化学》《药理学》《药剂学》《制药工艺学》《制药工程实训》和等本科课程及《创新药物研发前沿》《科技论文写作》等研究生课程教学;主持教研教改项目1项,发表教改论文2篇;指导研究生19名,指导大学生创新创业项目5项;。
代表性学术成果:
1. Airway-applied mRNA vaccine needs tailored sequence design and high standard purification that removes devastating dsRNA contaminant[J]. Molecular Therapy, 2025, 33(9): 4193-4215.
2. Solanum nigrum L-derived carbon Dots:Antimicrobial applications and detection of ciprofloxacin in milk samples[J]. LWT, 2025, 230: 118217.
3. Facile synthesis of highly efficient fluorescent silicon quantum dots used for highly sensitive sensor of tetracycline in honey samples and antibacterial agent[J]. Food Chemistry, 2025, 467: 141844.
4. Discovery of novel tetrahydrobenzothiophene derivatives as MSBA inhibitors for antimicrobial agents[J]. Bioorganic Chemistry, 2024, 142: 106932.
5. Discovery of novel thiophene amide derivatives with potent antibacterial activity[J]. Bioorganic & Medicinal Chemistry Letters, 2026, 137: 130631.
6. Bifunctional P‐Doped Carbon Quantum Dots as Fluorometric Probes for Detection of Fe3+ and Its Antimicrobial Activity[J]. ChemistrySelect, 2025, 10(12): e202404990.
7. Synthesis of sulfur-doped carbon quantum dots from Solanum nigrum for ciprofloxacin detection in yogurt samples and antibacterial activity[J]. RSC Advances, 2025, 15(33): 27294-27299.
8. Design, Preparation and Activity Evaluation of Long-Acting Insulin Analogues[J]. The Protein Journal, 2026, 45(2): 422-430.
9. High-Yield Biosynthesis Process for Producing Insulin Lispro[J]. The Protein Journal, 2025, 44(4): 363-376.
10. Preparation, Characterization, and Antibacterial Activity of Rhodiola Carbon Dots[J]. Russian Journal of General Chemistry, 2024, 94(8): 1991-1996.
11. TBHP/Et3 N-Promoted Chemoselective Formylation and Peroxidation of Pyrrolo[2,1- a ]isoquinolines[J]. The Journal of Organic Chemistry, 2024, 89(9): 6353-6363.
12. Iron-Catalyzed Synthesis of Peroxylpyrrolo[2,1- a ]isoquinolines through Oxidative Dearomatization[J]. The Journal of Organic Chemistry, 2023, 88(21): 15326-15334.
13. Iron-catalyzed dimerization of pyrrolo[2,1-a]isoquinolines and pyrrolo[1,2-a]quinolines[J]. Tetrahedron Letters, 2023, 126: 154657.
14. Fabrication of Carbon Quantum Dots From Caesalpinia sappan L. for Antibacterial Applications and Fluorescent Detection of Ciprofloxacin[J]. ChemistrySelect, 2026, 11(14): e06794.
15. Plant-Derived Nitrogen-Doped Carbon Quantum Dots for Selective Cu2+ Detection and In Vivo Fluorescence Imaging[J]. Journal of Fluorescence, 2026, 36(6): 3741-3751.
16.新型吲哚系列小分子化合物设计及合成(横向)
17.二硒硅源的合成(横向)
18.高性能碳纤维的开发(横向)
19.抗流感病毒类Nucleozin衍生物的设计、合成和生物活性评价(纵向,重庆市科学技术局)
20.脂多糖生物合成抑制剂的设计合成和抗菌活性研究;(纵向,重庆市教育委员会)
21.长效胰岛素类似物的设计、制备及降血糖活性评价(纵向,北京药师协会)
22.基于中药龙葵的碳量子点的制备及其抗菌活性研究(纵向,成都大学)